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Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition

An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify...

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Detalles Bibliográficos
Autores principales: Mazza, Giuseppe, Telese, Andrea, Al-Akkad, Walid, Frenguelli, Luca, Levi, Ana, Marrali, Martina, Longato, Lisa, Thanapirom, Kessarin, Vilia, Maria Giovanna, Lombardi, Benedetta, Crowley, Claire, Crawford, Mark, Karsdal, Morten A., Leeming, Diana J., Marrone, Giusi, Bottcher, Katrin, Robinson, Benjamin, Del Rio Hernandez, Armando, Tamburrino, Domenico, Spoletini, Gabriele, Malago, Massimo, Hall, Andrew R., Godovac-Zimmermann, Jasminka, Luong, Tu Vinh, De Coppi, Paolo, Pinzani, Massimo, Rombouts, Krista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017194/
https://www.ncbi.nlm.nih.gov/pubmed/31905709
http://dx.doi.org/10.3390/cells9010083