ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia. The implication of the fusion protein in leukemogenesis seems to be clear. However, its role in the maintenance of the disease...

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Detalles Bibliográficos
Autores principales: Montaño, Adrián, Ordoñez, Jose Luis, Alonso-Pérez, Verónica, Hernández-Sánchez, Jesús, Santos, Sandra, González, Teresa, Benito, Rocío, García-Tuñón, Ignacio, Hernández-Rivas, Jesús María
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017301/
https://www.ncbi.nlm.nih.gov/pubmed/31952221
http://dx.doi.org/10.3390/cells9010215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017301/
https://www.ncbi.nlm.nih.gov/pubmed/31952221
http://dx.doi.org/10.3390/cells9010215

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