Cargando…

Stromal Features of the Primary Tumor Are Not Prognostic in Genetically Engineered Mice of Pancreatic Cancer

The Kras(G12D/+);LSL-Trp53(R172H/+);Pdx-1-Cre (KPC) mouse model is frequently employed for preclinical therapeutic testing, in particular in regard to antistromal therapies. Here, we investigate the prognostic implications of histopathological features that may guide preclinical trial design. Pancre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hasselluhn, Marie C., Klein, Lukas, Patzak, Melanie S., Buchholz, Sören M., Ströbel, Philipp, Ellenrieder, Volker, Maisonneuve, Patrick, Neesse, Albrecht
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017324/ https://www.ncbi.nlm.nih.gov/pubmed/31878349 http://dx.doi.org/10.3390/cells9010058

Ejemplares similares

SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer
por: Ramu, Iswarya, et al.
Publicado: (2019)

Systemic IgG4-Related Disease Masquerading as Cholangiocarcinoma: A Case Report Underscoring the Importance of Medical History
por: Gummlich, Benjamin P.M., et al.
Publicado: (2021)

Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer
por: Goetze, Robert G., et al.
Publicado: (2019)

Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer
por: Patil, Shilpa, et al.
Publicado: (2021)

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression
por: Hasselluhn, Marie C., et al.
Publicado: (2019)

TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer
por: Versemann, Lennart, et al.
Publicado: (2022)

Activity of acute pancreatitis is modified by secreted protein acidic and rich in cysteine ablation
por: Ammer‐Herrmenau, Christoph, et al.
Publicado: (2022)

Urokinase-Type Plasminogen Activator Receptor (uPAR) Cooperates with Mutated KRAS in Regulating Cellular Plasticity and Gemcitabine Response in Pancreatic Adenocarcinomas
por: Peng, Luogen, et al.
Publicado: (2023)

Simultaneous Onset of Ulcerative Colitis and Disseminated Pyoderma Gangrenosum
por: Neesse, Albrecht, et al.
Publicado: (2007)

Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer
por: Krebs, Niklas, et al.
Publicado: (2022)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation
por: Hessmann, Elisabeth, et al.
Publicado: (2016)

Gall bladder wall thickening as non-invasive screening parameter for esophageal varices – a comparative endoscopic – sonographic study
por: Tsaknakis, Birgit, et al.
Publicado: (2018)

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice
por: Neesse, Albrecht, et al.
Publicado: (2014)

Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer
por: Buchholz, Soeren M., et al.
Publicado: (2020)

Serum vitamin D but not zinc levels are associated with different disease activity status in patients with inflammatory bowel disease
por: Mechie, Nicolae-Catalin, et al.
Publicado: (2019)

Akute nekrotisierende Pankreatitis mit hämorrhagischem Schock bei sekundärer Milzruptur: Ein Fallbericht und Literaturübersicht
por: Kaiser, Leon, et al.
Publicado: (2023)

Pantoprazole Does not Affect Serum Trough Levels of Tacrolimus and Everolimus in Liver Transplant Recipients
por: Bremer, Sebastian C. B., et al.
Publicado: (2018)

Tunnelled Peritoneal Catheter for Malignant Ascites—An Open-Label, Prospective, Observational Trial
por: Petzold, Golo, et al.
Publicado: (2021)

Comparison of Chest Ultrasound and Standard X-Ray Imaging in COVID-19 Patients
por: Shumilov, Evgenii, et al.
Publicado: (2020)

Severe Acute Respiratory Distress Syndrome during Infliximab Therapy in a Patient with Crohn Disease
por: Schoehl, Johanna, et al.
Publicado: (2016)

Cytomegalovirus colitis in inflammatory bowel disease and after haematopoietic stem cell transplantation: diagnostic accuracy, predictors, risk factors and disease outcome
por: Mavropoulou, Eirini, et al.
Publicado: (2019)

Endoscopic mucosal resection with an additional working channel (EMR+) in a porcine ex vivo model: a novel technique to improve en bloc resection rate of snare polypectomy
por: Knoop, Richard F., et al.
Publicado: (2020)

Diagnostic accuracy of B-Mode ultrasound and Hepatorenal Index for graduation of hepatic steatosis in patients with chronic liver disease
por: Petzold, Golo, et al.
Publicado: (2020)

Endoscopic submucosal dissection with an additional working channel (ESD+): a novel technique to improve procedure time and safety of ESD
por: Knoop, Richard F., et al.
Publicado: (2020)

Endoscopic mucosal resection and endoscopic submucosal dissection with an external additional working channel (EMR+ and ESD+) are equivalent to using a double-channel endoscope: a systematic evaluation in a porcine ex vivo model
por: Knoop, Richard F., et al.
Publicado: (2023)

Systematic Retesting for Helicobacter pylori: The Potential Overestimation of Suppressive Conditions
por: Knoop, Richard F., et al.
Publicado: (2022)

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
por: Neesse, Albrecht, et al.
Publicado: (2013)

The microbiome in pancreatic diseases: Recent advances and future perspectives
por: Ammer-Herrmenau, Christoph, et al.
Publicado: (2020)

Anti-Tumour Efficacy of Capecitabine in a Genetically Engineered Mouse Model of Pancreatic Cancer
por: Courtin, Aurélie, et al.
Publicado: (2013)

Cure Is Possible: Extensively Metastatic HER2-Positive Gastric Carcinoma with 5 years of Complete Remission after Therapy with the FLOT Regimen and Trastuzumab
por: Schade, Sebastian, et al.
Publicado: (2022)

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?
por: Hessmann, Elisabeth, et al.
Publicado: (2017)

Study protocol P-MAPS: microbiome as predictor of severity in acute pancreatitis—a prospective multicentre translational study
por: Ammer-Herrmenau, C., et al.
Publicado: (2021)

Epithelial to Stromal Re-Distribution of Primary Cilia during Pancreatic Carcinogenesis
por: Schimmack, Simon, et al.
Publicado: (2016)

Current management and prognostic features for gastrointestinal stromal tumor (GIST)
por: Lamba, Gurpreet, et al.
Publicado: (2012)

SALL4‐related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features
por: Vienot, Angélique, et al.
Publicado: (2023)

Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
por: Villard, Orianne, et al.
Publicado: (2020)

Stromal Palladin Expression Is an Independent Prognostic Factor in Pancreatic Ductal Adenocarcinoma
por: Sato, Daisuke, et al.
Publicado: (2016)

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
por: Hessmann, E, et al.
Publicado: (2018)

Correction to: Characterization of immortalized human islet stromal cells reveals a MSC-like profile with pancreatic features
por: Villard, Orianne, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_kg8rdljpgc1guta563p23ff6rg