Stabilization of Active Site Dynamics Leads to Increased Activity with 3′-Azido-3′-deoxythymidine Monophosphate for F105Y Mutant Human Thymidylate Kinase

[Image: see text] Thymidylate kinases are essential enzymes with roles in DNA synthesis and repair and have been the target of drug development for antimalarials, antifungals, HIV treatment, and cancer therapeutics. Human thymidylate kinase (hTMPK) conversion of the anti-HIV prodrug 3′-azido-3′-deox...

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Detalles Bibliográficos
Autores principales: Fucci, Ian J., Sinha, Kaustubh, Rule, Gordon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017412/
https://www.ncbi.nlm.nih.gov/pubmed/32064397
http://dx.doi.org/10.1021/acsomega.9b03766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017412/
https://www.ncbi.nlm.nih.gov/pubmed/32064397
http://dx.doi.org/10.1021/acsomega.9b03766

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