GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1

Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transcriptional co-activators YAP/TAZ. We were interested...

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Detalles Bibliográficos
Autores principales: Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018035/
https://www.ncbi.nlm.nih.gov/pubmed/32053631
http://dx.doi.org/10.1371/journal.pone.0228195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018035/
https://www.ncbi.nlm.nih.gov/pubmed/32053631
http://dx.doi.org/10.1371/journal.pone.0228195

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