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GPCR-induced YAP activation sensitizes fibroblasts to profibrotic activity of TGFβ1
Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transcriptional co-activators YAP/TAZ. We were interested...
Autores principales: | Zmajkovicova, Katarina, Bauer, Yasmina, Menyhart, Katalin, Schnoebelen, Marie, Freti, Diego, Boucher, Maxime, Renault, Bérengère, Studer, Rolf, Birker-Robaczewska, Magdalena, Klenk, Axel, Nayler, Oliver, Gatfield, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018035/ https://www.ncbi.nlm.nih.gov/pubmed/32053631 http://dx.doi.org/10.1371/journal.pone.0228195 |
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