Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer

Cancer genomes with mutations in the exonuclease domain of Polymerase Epsilon (POLE) present with an extraordinarily high somatic mutation burden. In vitro studies have shown that distinct POLE mutants exhibit different polymerase activity. Yet, genome-wide mutation patterns and driver mutation form...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Hu, Barbour, Jayne A., Poulos, Rebecca C., Katainen, Riku, Aaltonen, Lauri A., Wong, Jason W. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018097/
https://www.ncbi.nlm.nih.gov/pubmed/32012149
http://dx.doi.org/10.1371/journal.pgen.1008572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018097/
https://www.ncbi.nlm.nih.gov/pubmed/32012149
http://dx.doi.org/10.1371/journal.pgen.1008572

Ejemplares similares