Cargando…

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri

Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites, such as gliotoxin. Gliotoxin is known to inhibit the host immune response, and genetic mutants that inactivate gli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knowles, Sonja L., Mead, Matthew E., Silva, Lilian Pereira, Raja, Huzefa A., Steenwyk, Jacob L., Goldman, Gustavo H., Oberlies, Nicholas H., Rokas, Antonis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2020
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018655/ https://www.ncbi.nlm.nih.gov/pubmed/32047138 http://dx.doi.org/10.1128/mBio.03361-19

Ejemplares similares

Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus
por: Mead, Matthew E., et al.
Publicado: (2019)

Regulation of gliotoxin biosynthesis and protection in Aspergillus species
por: de Castro, Patrícia Alves, et al.
Publicado: (2022)

Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis
por: dos Santos, Renato A. C., et al.
Publicado: (2020)

Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
por: Knowles, Sonja L., et al.
Publicado: (2020)

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence
por: Ries, Laure N. A., et al.
Publicado: (2020)

The Role of Zinc in Gliotoxin Biosynthesis of Aspergillus fumigatus
por: Seo, Hyewon, et al.
Publicado: (2019)

Extensive Non-Coding Sequence Divergence Between the Major Human Pathogen Aspergillus fumigatus and its Relatives
por: Brown, Alec, et al.
Publicado: (2022)

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus
por: Steenwyk, Jacob L., et al.
Publicado: (2020)

Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatus
por: Steenwyk, Jacob L., et al.
Publicado: (2021)

Evolving moldy murderers: Aspergillus section Fumigati as a model for studying the repeated evolution of fungal pathogenicity
por: Rokas, Antonis, et al.
Publicado: (2020)

Induction of Gliotoxin Secretion in Aspergillus fumigatus by Bacteria-Associated Molecules
por: Svahn, K. Stefan, et al.
Publicado: (2014)

Vacuoles and peroxisomes are involved in Aspergillus fumigatus gliotoxin production and self-protection
por: de Castro, Patrícia Alves, et al.
Publicado: (2023)

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus
por: Dolan, Stephen K., et al.
Publicado: (2017)

Molecular characterization of gliotoxin-producing Aspergillus fumigatus in dairy cattle feed
por: Mohamed, Hams M. A., et al.
Publicado: (2023)

The evolution of the gliotoxin biosynthetic gene cluster in Penicillium fungi
por: Balamurugan, Charu, et al.
Publicado: (2023)

Self-Protection against Gliotoxin—A Component of the Gliotoxin Biosynthetic Cluster, GliT, Completely Protects Aspergillus fumigatus Against Exogenous Gliotoxin
por: Schrettl, Markus, et al.
Publicado: (2010)

In vitro activity of chlorogenic acid against Aspergillus fumigatus biofilm and gliotoxin production
por: Kong, Jin-Liang, et al.
Publicado: (2017)

Examination of Genome-Wide Ortholog Variation in Clinical and Environmental Isolates of the Fungal Pathogen Aspergillus fumigatus
por: Horta, Maria Augusta C., et al.
Publicado: (2022)

At the metal–metabolite interface in Aspergillus fumigatus: towards untangling the intersecting roles of zinc and gliotoxin
por: Traynor, Aimee M., et al.
Publicado: (2021)

Exposure of Aspergillus fumigatus to Klebsiella pneumoniae Culture Filtrate Inhibits Growth and Stimulates Gliotoxin Production
por: Curtis, Aaron, et al.
Publicado: (2023)

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2021)

RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus
por: O’Keeffe, Grainne, et al.
Publicado: (2014)

Draft Genome Sequence of the Griseofulvin-Producing Fungus Xylaria flabelliformis Strain G536
por: Mead, Matthew E., et al.
Publicado: (2019)

Draft Genome Sequences of Four Aspergillus Section Fumigati Clinical Strains
por: dos Santos, Renato Augusto Corrêa, et al.
Publicado: (2020)

Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus
por: Lim, Fang Yun, et al.
Publicado: (2018)

Examining Signatures of Natural Selection in Antifungal Resistance Genes Across Aspergillus Fungi
por: dos Santos, Renato Augusto Corrêa, et al.
Publicado: (2021)

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice
por: Pardo, Julian, et al.
Publicado: (2006)

Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives
por: Hatmaker, E. Anne, et al.
Publicado: (2022)

A Robust Phylogenomic Time Tree for Biotechnologically and Medically Important Fungi in the Genera Aspergillus and Penicillium
por: Steenwyk, Jacob L., et al.
Publicado: (2019)

The Aspergillus fumigatus Mismatch Repair MSH2 Homolog Is Important for Virulence and Azole Resistance
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2019)

Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells
por: Zhang, Changjian, et al.
Publicado: (2019)

A phylogenetic approach to explore the Aspergillus fumigatus conidial surface-associated proteome and its role in pathogenesis
por: Goldman, Gustavo, et al.
Publicado: (2023)

Regulation of Development in Aspergillus nidulans and Aspergillus fumigatus
por: Yu, Jae-Hyuk
Publicado: (2010)

Investigation of Aspergillus fumigatus biofilm formation by various “omics” approaches
por: Muszkieta, Laetitia, et al.
Publicado: (2013)

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
por: Jain, Radhika, et al.
Publicado: (2011)

Aspergillus fumigatus in Poultry
por: Arné, Pascal, et al.
Publicado: (2011)

Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2019)

The Fumagillin Gene Cluster, an Example of Hundreds of Genes under veA Control in Aspergillus fumigatus
por: Dhingra, Sourabh, et al.
Publicado: (2013)

Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
por: Mattos, Eliciane Cevolani, et al.
Publicado: (2020)

Antioxidant Activity of Aspergillus fumigatus
por: Arora, Daljit Singh, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9csn7fasrpia65m3gqkin6hcrq