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Nuclear receptor HNF4α performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence

Hepatocyte nuclear factor 4α (HNF4α, NR2A1) is a highly conserved member of the nuclear receptor superfamily. Recent advances reveal that it is a key transcriptional regulator of genes, broadly involved in xenobiotic and drug metabolism and also cancers of gastrointestinal tract. However, the exact...

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Detalles Bibliográficos
Autores principales:	Wang, Zhu, Li, Youjia, Wu, Dinglan, Yu, Shan, Wang, Yuliang, Leung Chan, Franky
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018660/ https://www.ncbi.nlm.nih.gov/pubmed/31695151 http://dx.doi.org/10.1038/s41388-019-1080-3

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