TGF-β1 Augments the Apical Membrane Abundance of Lemur Tyrosine Kinase 2 to Inhibit CFTR-Mediated Chloride Transport in Human Bronchial Epithelia

The most common disease-causing mutation in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, F508del, leads to cystic fibrosis (CF), by arresting CFTR processing and trafficking to the plasma membrane. The FDA-approved modulators partially restore CFTR function and slow down the...

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Detalles Bibliográficos
Autores principales: Cruz, Daniel F., Mitash, Nilay, Farinha, Carlos M., Swiatecka-Urban, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018669/
https://www.ncbi.nlm.nih.gov/pubmed/32117984
http://dx.doi.org/10.3389/fcell.2020.00058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018669/
https://www.ncbi.nlm.nih.gov/pubmed/32117984
http://dx.doi.org/10.3389/fcell.2020.00058

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