Clonal Selection of a Novel Deleterious TP53 Somatic Mutation Discovered in ctDNA of a KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumor Resistant to Imatinib

The standard of care for the first-line treatment of advanced gastrointestinal stromal tumor (GIST) is represented by imatinib, which is given daily at a standard dosage until tumor progression. Resistance to imatinib commonly occurs through the clonal selection of genetic mutations in the tumor DNA...

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Detalles Bibliográficos
Autores principales: Dalle Fratte, Chiara, Guardascione, Michela, De Mattia, Elena, Borsatti, Eugenio, Boschetto, Roberta, Farruggio, Angelo, Canzonieri, Vincenzo, Romanato, Loredana, Borsatti, Rachele, Gagno, Sara, Marangon, Elena, Polano, Maurizio, Buonadonna, Angela, Toffoli, Giuseppe, Cecchin, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019050/
https://www.ncbi.nlm.nih.gov/pubmed/32116712
http://dx.doi.org/10.3389/fphar.2020.00036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019050/
https://www.ncbi.nlm.nih.gov/pubmed/32116712
http://dx.doi.org/10.3389/fphar.2020.00036

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