Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics

The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the cellular receptor Niemann-Pick C1 protein (NPC1) are essential step...

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Detalles Bibliográficos
Autores principales: Durham, Natasha D., Howard, Angela R., Govindan, Ramesh, Senjobe, Fernando, Fels, J. Maximilian, Diehl, William E., Luban, Jeremy, Chandran, Kartik, Munro, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019799/
https://www.ncbi.nlm.nih.gov/pubmed/31952255
http://dx.doi.org/10.3390/v12010103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019799/
https://www.ncbi.nlm.nih.gov/pubmed/31952255
http://dx.doi.org/10.3390/v12010103

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