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Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor

The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. Different viruses have similarly exploited this concept by expressing a set...

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Detalles Bibliográficos
Autores principales: Alejo, Alí, Sánchez, Carolina, Amu, Sylvie, Fallon, Padraic G., Alcamí, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020083/
https://www.ncbi.nlm.nih.gov/pubmed/31877657
http://dx.doi.org/10.3390/jcm9010025