Impact of phenylalanine on cognitive, cerebral, and neurometabolic parameters in adult patients with phenylketonuria (the PICO study): a randomized, placebo-controlled, crossover, noninferiority trial

BACKGROUND: The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood phenylalanine (Phe) levels in adults outside pregnancy is a matter of debate. Therefore, prospective intervention studies are ne...

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Detalles Bibliográficos
Autores principales: Trepp, Roman, Muri, Raphaela, Abgottspon, Stephanie, Bosanska, Lenka, Hochuli, Michel, Slotboom, Johannes, Rummel, Christian, Kreis, Roland, Everts, Regula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020385/
https://www.ncbi.nlm.nih.gov/pubmed/32054509
http://dx.doi.org/10.1186/s13063-019-4022-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020385/
https://www.ncbi.nlm.nih.gov/pubmed/32054509
http://dx.doi.org/10.1186/s13063-019-4022-z

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