Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BACKGROUND: In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at metamorphosis; the larger number and higher levels...

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Detalles Bibliográficos
Autores principales: Khan, Anzer, Paro, Simona, McGurk, Leeanne, Sambrani, Nagraj, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020516/
https://www.ncbi.nlm.nih.gov/pubmed/32059717
http://dx.doi.org/10.1186/s12915-020-0747-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020516/
https://www.ncbi.nlm.nih.gov/pubmed/32059717
http://dx.doi.org/10.1186/s12915-020-0747-0

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