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The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents
BACKGROUND: Naphthoquine (NQ) is a suitable partner anti-malarial for the artemisinin-based combination therapy (ACT), which is recommended to be taken orally as a single-dose regimen. The metabolism of NQ was mainly mediated by CYP2D6, which is well-known to show gender-specific differences in its...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020547/ https://www.ncbi.nlm.nih.gov/pubmed/32054478 http://dx.doi.org/10.1186/s12936-020-3153-8 |