Cargando…

Dexmedetomidine Exerted Anti-arrhythmic Effects in Rat With Ischemic Cardiomyopathy via Upregulation of Connexin 43 and Reduction of Fibrosis and Inflammation

BACKGROUND: Persistent myocardial ischemia post-myocardial infarction can lead to fatal ventricular arrhythmias such as ventricular tachycardia and fibrillation, both of which carry high mortality rates. Dexmedetomidine (Dex) is a highly selective α2-agonist used in surgery for congenital cardiac di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Shu-jie, Lin, Zhong-hao, Lin, Yuan-zheng, Rao, Zhi-heng, Lin, Jia-feng, Wu, Lian-pin, Li, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020758/ https://www.ncbi.nlm.nih.gov/pubmed/32116751 http://dx.doi.org/10.3389/fphys.2020.00033

Ejemplares similares

The Importance of Connexin 43 in Enamel Development and Mineralization
por: Al-Ansari, Sali, et al.
Publicado: (2018)

Connexin 43 hemichannels and intracellular signaling in bone cells
por: Plotkin, Lilian I.
Publicado: (2014)

Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning
por: Whisenant, Claire C., et al.
Publicado: (2022)

Control of Vascular Smooth Muscle Cell Growth by Connexin 43
por: Joshi, Chintamani N., et al.
Publicado: (2012)

The Role of Connexin 43 and Pannexin 1 During Acute Inflammation
por: Kameritsch, Petra, et al.
Publicado: (2020)

Machine Learning Identification of Pro-arrhythmic Structures in Cardiac Fibrosis
por: Halfar, Radek, et al.
Publicado: (2021)

Stem cells can form gap junctions with cardiac myocytes and exert pro-arrhythmic effects
por: Smit, Nicoline W., et al.
Publicado: (2014)

Conjugated Linoleic Acid-Mediated Connexin-43 Remodeling and Sudden Arrhythmic Death in Myocardial Infarction
por: Kelm, Natia Qipshidze, et al.
Publicado: (2023)

Connexin 43 Channels in Osteocytes Regulate Bone Responses to Mechanical Unloading
por: Zhao, Dezhi, et al.
Publicado: (2020)

Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
por: Mostafavi, Hossein, et al.
Publicado: (2014)

Chronic Kidney Disease Increases Atrial Fibrillation Inducibility: Involvement of Inflammation, Atrial Fibrosis, and Connexins
por: Qiu, Huiliang, et al.
Publicado: (2018)

O-GlcNAcylation Inhibition Upregulates Connexin43 Expression in the Endothelium to Protect the Tight Junction Barrier in Diabetic Retinopathy
por: Liu, Guodong, et al.
Publicado: (2023)

Omega-3 Fatty Acids: Anti-Arrhythmic, Pro-Arrhythmic, or Both?
por: von Schacky, C.
Publicado: (2012)

Connexin 43 in Mitochondria: What Do We Really Know About Its Function?
por: Boengler, Kerstin, et al.
Publicado: (2022)

Distinct ECG Phenotypes Identified in Hypertrophic Cardiomyopathy Using Machine Learning Associate With Arrhythmic Risk Markers
por: Lyon, Aurore, et al.
Publicado: (2018)

Omega 3 fatty acid inhibition of inflammatory cytokine-mediated Connexin43 regulation in the heart
por: Baum, Jennifer R., et al.
Publicado: (2012)

Connexin43 Hemichannel-Mediated Regulation of Connexin43
por: Li, Kai, et al.
Publicado: (2013)

Mono-Heteromeric Configurations of Gap Junction Channels Formed by Connexin43 and Connexin45 Reduce Unitary Conductance and Determine both Voltage Gating and Metabolic Flux Asymmetry
por: Zhong, Guoqiang, et al.
Publicado: (2017)

Anti-arrhythmic Cardiac Phenotype Elicited by Chronic Intermittent Hypoxia Is Associated With Alterations in Connexin-43 Expression, Phosphorylation, and Distribution
por: Kohutova, Jana, et al.
Publicado: (2019)

Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome
por: Nademanee, Koonlawee, et al.
Publicado: (2015)

Downregulation of Retinal Connexin 43 in GFAP-Expressing Cells Modifies Vasoreactivity Induced by Perfusion Ocular Pressure Changes
por: Liu, Guodong, et al.
Publicado: (2021)

Pro-arrhythmic Effects of Hydrogen Sulfide in Healthy and Ischemic Cardiac Tissues: Insight From a Simulation Study
por: Zhang, Shugang, et al.
Publicado: (2019)

Suppression of Connexin 43 Leads to Strial Vascular Hyper-Permeability, Decrease in Endocochlear Potential, and Mild Hearing Loss
por: Zhang, Jinhui, et al.
Publicado: (2020)

Connexin 43-Mediated Gap Junction Communication Regulates Ameloblast Differentiation via ERK1/2 Phosphorylation
por: Yamada, Aya, et al.
Publicado: (2021)

Function of a novel plakophilin-2 mutation in the abnormal expression of connexin43 in a patient with arrhythmogenic right ventricular cardiomyopathy
por: WANG, PEI-NING, et al.
Publicado: (2015)

Morphine Induces Fibroblast Activation through Up-regulation of Connexin 43 Expression: Implication of Fibrosis in Wound Healing
por: Wu, Ping-Ching, et al.
Publicado: (2018)

Connexin 43 Upregulation in Mouse Lungs during Ovalbumin-Induced Asthma
por: Yao, Yin, et al.
Publicado: (2015)

The Effects of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Cardiac Rhythm: Anti-Arrhythmic, Pro-Arrhythmic, Both or Neither? It Depends…
por: Rauch, Bernhard, et al.
Publicado: (2012)

Protein Kinase C-Mediated Hyperphosphorylation and Lateralization of Connexin 43 Are Involved in Autoimmune Myocarditis-Induced Prolongation of QRS Complex
por: Zhong, Chunlian, et al.
Publicado: (2022)

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments
por: Leybaert, Luc, et al.
Publicado: (2023)

Connexin 43 and Connexin 26 Involvement in the Ponatinib-Induced Cardiomyopathy: Sex-Related Differences in a Murine Model
por: Madonna, Rosalinda, et al.
Publicado: (2021)

Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells
por: Chai, Yunfei, et al.
Publicado: (2020)

Eicosapentaenoic acids enhance chemosensitivity through connexin 43 upregulation in murine melanoma models
por: Yang, Chih-Jen, et al.
Publicado: (2019)

Anti-Arrhythmic Effect of Verapamil Is Accompanied by Preservation of Cx43 Protein in Rat Heart
por: Zhou, Peng, et al.
Publicado: (2013)

Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion—involvement of intracellular Ca(2+) and connexin 43
por: Gao, Junhong, et al.
Publicado: (2015)

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions
por: Liang, Zhen, et al.
Publicado: (2020)

Arrhythmogenic Cardiomyopathy: Exercise Pitfalls, Role of Connexin-43, and Moving beyond Antiarrhythmics
por: Coscarella, Isabella Leite, et al.
Publicado: (2022)

Connexin 37 and Connexin 43 genotypes in correlation to cytokines in induced sputum and blood in cystic fibrosis (CF)
por: Ludwig, M, et al.
Publicado: (2014)

Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition
por: Wang, Yijia, et al.
Publicado: (2020)

Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP
por: TenBroek, Erica M., et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_h2ciof6l0523rb3lorau9jj5f4