Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH(2), and stabilise 14–18 membered rings that mimic dif...

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Detalles Bibliográficos
Autores principales: Hoang, Huy N., Hill, Timothy A., Ruiz-Gómez, Gloria, Diness, Frederik, Mason, Jody M., Wu, Chongyang, Abbenante, Giovanni, Shepherd, Nicholas E., Fairlie, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020788/
https://www.ncbi.nlm.nih.gov/pubmed/32110345
http://dx.doi.org/10.1039/c9sc04153b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020788/
https://www.ncbi.nlm.nih.gov/pubmed/32110345
http://dx.doi.org/10.1039/c9sc04153b

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