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Twists or turns: stabilising alpha vs. beta turns in tetrapeptides
Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH(2), and stabilise 14–18 membered rings that mimic dif...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020788/ https://www.ncbi.nlm.nih.gov/pubmed/32110345 http://dx.doi.org/10.1039/c9sc04153b |