Caspase-3 Promotes Diabetic Kidney Disease Through Gasdermin E-Mediated Progression to Secondary Necrosis During Apoptosis

BACKGROUND: Apoptosis has been repeatedly linked with diabetic kidney disease (DKD), which is a programmed cell death mediated by effector caspases-3, 6 and 7, targeting >600 substrates. However, the pathophysiologic correlations of this process remain obscure. As a putative tumor suppressor, gas...

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Detalles Bibliográficos
Autores principales: Wen, Si, Wang, Zhao-Hua, Zhang, Cong-Xiao, Yang, Ying, Fan, Qiu-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020918/
https://www.ncbi.nlm.nih.gov/pubmed/32104028
http://dx.doi.org/10.2147/DMSO.S242136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020918/
https://www.ncbi.nlm.nih.gov/pubmed/32104028
http://dx.doi.org/10.2147/DMSO.S242136

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