A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53

The physiological effects of the many germline mutations of TP53, encoding the tumor suppressor protein p53, are poorly understood. Here we report generating a p53 R178C knockin mouse modeling the human TP53 R181C mutation, which is notable for its prevalence and prior molecular characterization. Co...

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Detalles Bibliográficos
Autores principales: Kang, Ju-Gyeong, Lago, Cory U., Lee, Ji-Eun, Park, Ji-Hoon, Donnelly, Matthew P., Starost, Matthew F., Liu, Chengyu, Kwon, Jaeyul, Noguchi, Audrey C., Ge, Kai, Wang, Ping-yuan, Hwang, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021448/
https://www.ncbi.nlm.nih.gov/pubmed/31968253
http://dx.doi.org/10.1016/j.celrep.2019.12.074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021448/
https://www.ncbi.nlm.nih.gov/pubmed/31968253
http://dx.doi.org/10.1016/j.celrep.2019.12.074

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