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A Mouse Homolog of a Human TP53 Germline Mutation Reveals a Lipolytic Activity of p53
The physiological effects of the many germline mutations of TP53, encoding the tumor suppressor protein p53, are poorly understood. Here we report generating a p53 R178C knockin mouse modeling the human TP53 R181C mutation, which is notable for its prevalence and prior molecular characterization. Co...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021448/ https://www.ncbi.nlm.nih.gov/pubmed/31968253 http://dx.doi.org/10.1016/j.celrep.2019.12.074 |