PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential

The RET proto-oncogene encodes receptor tyrosine kinase, expressed primarily in tissues of neural crest origin. De-regulation of RET signaling is implicated in several human cancers. Recent phosphatome interactome analysis identified PTPRA interacting with the neurotrophic factor (GDNF)-dependent RE...

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Detalles Bibliográficos
Autores principales: Yadav, Leena, Pietilä, Elina, Öhman, Tiina, Liu, Xiaonan, Mahato, Arun K., Sidorova, Yulia, Lehti, Kaisa, Saarma, Mart, Varjosalo, Markku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021549/
https://www.ncbi.nlm.nih.gov/pubmed/32062451
http://dx.doi.org/10.1016/j.isci.2020.100871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021549/
https://www.ncbi.nlm.nih.gov/pubmed/32062451
http://dx.doi.org/10.1016/j.isci.2020.100871

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