Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fer...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021556/ https://www.ncbi.nlm.nih.gov/pubmed/32082990 http://dx.doi.org/10.1016/j.toxrep.2020.02.004 |
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author | Rahman, Mohammad Shadiqur Islam, S M Majharul Haque, Anamul Shahjahan, Md. |
author_facet | Rahman, Mohammad Shadiqur Islam, S M Majharul Haque, Anamul Shahjahan, Md. |
author_sort | Rahman, Mohammad Shadiqur |
collection | PubMed |
description | Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fertilized egg (n = 100) and larvae (n = 100) were exposed to six concentrations of sumithion (0, 0.1, 0.2, 0.4, 0.8 and 1.6 mg L(−1)) in three replicates. LC(50) values for embryos and larvae were calculated by probit analysis. The 24 h LC(50) value of sumithion for embryo was 0.235 (0.079-0.428) mgL(−1). Increasing sumithion concentrations decreased hatching success and increased embryonic mortality. In embryos, sumithion induced several malformations including immature yolk sac, dark yolk sac, yolk sac bud, broken eggshell and notochord, unhatched eggs. Larval LC(50) values at 24, 48 and 72 h of various doses of sumithion exposure were 0.620 (0.436-0.963), 0.475 (0.302-0.801) and 0.341 (0.177-0.617) mgL(−1), respectively. Various physical deformities, including edema, notochord deformity, yolk sac damage, body arcuation, lordosis and black pigmentation on the yolk sac were evident in response to different concentrations of sumithion. The results of the current study indicate that sumithion exerts developmental toxicity to zebrafish embryos and larvae. It is expected that current findings will increase sensitivity about the toxic effect of sumithion in early development, as well the possibility of similar actions induced by other insecticides and pesticides. |
format | Online Article Text |
id | pubmed-7021556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70215562020-02-20 Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish Rahman, Mohammad Shadiqur Islam, S M Majharul Haque, Anamul Shahjahan, Md. Toxicol Rep Regular Article Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fertilized egg (n = 100) and larvae (n = 100) were exposed to six concentrations of sumithion (0, 0.1, 0.2, 0.4, 0.8 and 1.6 mg L(−1)) in three replicates. LC(50) values for embryos and larvae were calculated by probit analysis. The 24 h LC(50) value of sumithion for embryo was 0.235 (0.079-0.428) mgL(−1). Increasing sumithion concentrations decreased hatching success and increased embryonic mortality. In embryos, sumithion induced several malformations including immature yolk sac, dark yolk sac, yolk sac bud, broken eggshell and notochord, unhatched eggs. Larval LC(50) values at 24, 48 and 72 h of various doses of sumithion exposure were 0.620 (0.436-0.963), 0.475 (0.302-0.801) and 0.341 (0.177-0.617) mgL(−1), respectively. Various physical deformities, including edema, notochord deformity, yolk sac damage, body arcuation, lordosis and black pigmentation on the yolk sac were evident in response to different concentrations of sumithion. The results of the current study indicate that sumithion exerts developmental toxicity to zebrafish embryos and larvae. It is expected that current findings will increase sensitivity about the toxic effect of sumithion in early development, as well the possibility of similar actions induced by other insecticides and pesticides. Elsevier 2020-02-07 /pmc/articles/PMC7021556/ /pubmed/32082990 http://dx.doi.org/10.1016/j.toxrep.2020.02.004 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Rahman, Mohammad Shadiqur Islam, S M Majharul Haque, Anamul Shahjahan, Md. Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title | Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title_full | Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title_fullStr | Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title_full_unstemmed | Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title_short | Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
title_sort | toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021556/ https://www.ncbi.nlm.nih.gov/pubmed/32082990 http://dx.doi.org/10.1016/j.toxrep.2020.02.004 |
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