Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish

Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fer...

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Autores principales: Rahman, Mohammad Shadiqur, Islam, S M Majharul, Haque, Anamul, Shahjahan, Md.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021556/
https://www.ncbi.nlm.nih.gov/pubmed/32082990
http://dx.doi.org/10.1016/j.toxrep.2020.02.004
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author Rahman, Mohammad Shadiqur
Islam, S M Majharul
Haque, Anamul
Shahjahan, Md.
author_facet Rahman, Mohammad Shadiqur
Islam, S M Majharul
Haque, Anamul
Shahjahan, Md.
author_sort Rahman, Mohammad Shadiqur
collection PubMed
description Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fertilized egg (n = 100) and larvae (n = 100) were exposed to six concentrations of sumithion (0, 0.1, 0.2, 0.4, 0.8 and 1.6 mg L(−1)) in three replicates. LC(50) values for embryos and larvae were calculated by probit analysis. The 24 h LC(50) value of sumithion for embryo was 0.235 (0.079-0.428) mgL(−1). Increasing sumithion concentrations decreased hatching success and increased embryonic mortality. In embryos, sumithion induced several malformations including immature yolk sac, dark yolk sac, yolk sac bud, broken eggshell and notochord, unhatched eggs. Larval LC(50) values at 24, 48 and 72 h of various doses of sumithion exposure were 0.620 (0.436-0.963), 0.475 (0.302-0.801) and 0.341 (0.177-0.617) mgL(−1), respectively. Various physical deformities, including edema, notochord deformity, yolk sac damage, body arcuation, lordosis and black pigmentation on the yolk sac were evident in response to different concentrations of sumithion. The results of the current study indicate that sumithion exerts developmental toxicity to zebrafish embryos and larvae. It is expected that current findings will increase sensitivity about the toxic effect of sumithion in early development, as well the possibility of similar actions induced by other insecticides and pesticides.
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spelling pubmed-70215562020-02-20 Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish Rahman, Mohammad Shadiqur Islam, S M Majharul Haque, Anamul Shahjahan, Md. Toxicol Rep Regular Article Sumithion, a synthetic organophosphate, is widely used as an agricultural insecticide and for control of tiger bug (Cicindela spp.) in larval rearing for aquaculture. An experiment was conducted to examine the effects of sumithion on embryological and larval development of zebrafish Danio rerio. Fertilized egg (n = 100) and larvae (n = 100) were exposed to six concentrations of sumithion (0, 0.1, 0.2, 0.4, 0.8 and 1.6 mg L(−1)) in three replicates. LC(50) values for embryos and larvae were calculated by probit analysis. The 24 h LC(50) value of sumithion for embryo was 0.235 (0.079-0.428) mgL(−1). Increasing sumithion concentrations decreased hatching success and increased embryonic mortality. In embryos, sumithion induced several malformations including immature yolk sac, dark yolk sac, yolk sac bud, broken eggshell and notochord, unhatched eggs. Larval LC(50) values at 24, 48 and 72 h of various doses of sumithion exposure were 0.620 (0.436-0.963), 0.475 (0.302-0.801) and 0.341 (0.177-0.617) mgL(−1), respectively. Various physical deformities, including edema, notochord deformity, yolk sac damage, body arcuation, lordosis and black pigmentation on the yolk sac were evident in response to different concentrations of sumithion. The results of the current study indicate that sumithion exerts developmental toxicity to zebrafish embryos and larvae. It is expected that current findings will increase sensitivity about the toxic effect of sumithion in early development, as well the possibility of similar actions induced by other insecticides and pesticides. Elsevier 2020-02-07 /pmc/articles/PMC7021556/ /pubmed/32082990 http://dx.doi.org/10.1016/j.toxrep.2020.02.004 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Rahman, Mohammad Shadiqur
Islam, S M Majharul
Haque, Anamul
Shahjahan, Md.
Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title_full Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title_fullStr Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title_full_unstemmed Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title_short Toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
title_sort toxicity of the organophosphate insecticide sumithion to embryo and larvae of zebrafish
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021556/
https://www.ncbi.nlm.nih.gov/pubmed/32082990
http://dx.doi.org/10.1016/j.toxrep.2020.02.004
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