Comprehensive biophysical and functional study of ziv-aflibercept: characterization and forced degradation

Aflibercept (AFL) is an Fc fusion protein used in the treatment of colorectal cancers and different ophthalmological diseases. There are two medicines in which AFL is the active substance: Zaltrap and Eylea, referred as ziv-AFL and AFL respectively. No proper accelerated degradation studies were pub...

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Detalles Bibliográficos
Autores principales: Hermosilla, Jesús, Pérez-Robles, Raquel, Salmerón-García, Antonio, Casares, Salvador, Cabeza, Jose, Bones, Jonathan, Navas, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021693/
https://www.ncbi.nlm.nih.gov/pubmed/32060315
http://dx.doi.org/10.1038/s41598-020-59465-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021693/
https://www.ncbi.nlm.nih.gov/pubmed/32060315
http://dx.doi.org/10.1038/s41598-020-59465-7

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