Conformational changes upon gating of KirBac1.1 into an open-activated state revealed by solid-state NMR and functional assays

The conformational changes required for activation and K(+) conduction in inward-rectifier K(+) (Kir) channels are still debated. These structural changes are brought about by lipid binding. It is unclear how this process relates to fast gating or if the intracellular and extracellular regions of th...

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Detalles Bibliográficos
Autores principales: Amani, Reza, Borcik, Collin G., Khan, Nazmul H., Versteeg, Derek B., Yekefallah, Maryam, Do, Hoa Q., Coats, Heather R., Wylie, Benjamin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022178/
https://www.ncbi.nlm.nih.gov/pubmed/31980523
http://dx.doi.org/10.1073/pnas.1915010117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022178/
https://www.ncbi.nlm.nih.gov/pubmed/31980523
http://dx.doi.org/10.1073/pnas.1915010117

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