Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood–brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting pas...

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Detalles Bibliográficos
Autores principales: Dudek, Katarzyna A., Dion-Albert, Laurence, Lebel, Manon, LeClair, Katherine, Labrecque, Simon, Tuck, Ellen, Ferrer Perez, Carmen, Golden, Sam A., Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J., Menard, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022213/
https://www.ncbi.nlm.nih.gov/pubmed/31974313
http://dx.doi.org/10.1073/pnas.1914655117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022213/
https://www.ncbi.nlm.nih.gov/pubmed/31974313
http://dx.doi.org/10.1073/pnas.1914655117

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