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Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity

Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease. ApoE is commonly found in amyloid deposits of different origins, and its interaction with...

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Detalles Bibliográficos
Autores principales: Gharibyan, Anna L., Islam, Tohidul, Pettersson, Nina, Golchin, Solmaz A., Lundgren, Johanna, Johansson, Gabriella, Genot, Mélany, Schultz, Nina, Wennström, Malin, Olofsson, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022431/
https://www.ncbi.nlm.nih.gov/pubmed/31947546
http://dx.doi.org/10.3390/biom10010134