Kinetic, Thermodynamic, and Crystallographic Studies of 2-Triazolylthioacetamides as Verona Integron-Encoded Metallo-β-Lactamase 2 (VIM-2) Inhibitor

Inhibition of β-lactamases presents a promising strategy to restore the β-lactams antibacterial activity to resistant bacteria. In this work, we found that aromatic carboxyl substituted 2-triazolylthioacetamides 1a–j inhibited VIM-2, exhibiting an IC(50) value in the range of 20.6–58.6 μM. The struc...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiang, Yang, Zhang, Yue-Juan, Ge, Ying, Zhou, Yajun, Chen, Cheng, Wahlgren, Weixiao Yuan, Tan, Xiangshi, Chen, Xi, Yang, Ke-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022493/
https://www.ncbi.nlm.nih.gov/pubmed/31906402
http://dx.doi.org/10.3390/biom10010072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022493/
https://www.ncbi.nlm.nih.gov/pubmed/31906402
http://dx.doi.org/10.3390/biom10010072

Ejemplares similares