Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism

Glutathione (GSH) degradation plays an essential role in GSH homeostasis, which regulates cell survival, especially in cancer cells. Among human GSH degradation enzymes, the ChaC2 enzyme acts on GSH to form 5-l-oxoproline and Cys-Gly specifically in the cytosol. Here, we report the crystal structure...

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Detalles Bibliográficos
Autores principales: Nguyen, Yen T. K., Park, Joon Sung, Jang, Jun Young, Kim, Kyung Rok, Vo, Tam T. L., Kim, Kyu-Won, Han, Byung Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022552/
https://www.ncbi.nlm.nih.gov/pubmed/31878259
http://dx.doi.org/10.3390/biom10010031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022552/
https://www.ncbi.nlm.nih.gov/pubmed/31878259
http://dx.doi.org/10.3390/biom10010031

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