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Development of Level A In Vitro–Vivo Correlation for Electrosprayed Microspheres Containing Leuprolide: Physicochemical, Pharmacokinetic, and Pharmacodynamic Evaluation

This study optimized the preparation of electrosprayed microspheres containing leuprolide and developed an in vitro–in vivo correlation (IVIVC) model that enables mutual prediction between in vitro and in vivo dissolution. The pharmacokinetic (PK) and pharmacodynamic (PD) study of leuprolide was car...

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Detalles Bibliográficos
Autores principales: Lee, Dong-Seok, Kang, Dong Wook, Choi, Go-Wun, Choi, Han-Gon, Cho, Hea-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022573/
https://www.ncbi.nlm.nih.gov/pubmed/31906491
http://dx.doi.org/10.3390/pharmaceutics12010036