Fab-Arm Exchange Combined with Selective Protein A Purification Results in a Platform for Rapid Preparation of Monovalent Bispecific Antibodies Directly from Culture Media

Bispecific antibody (bsAb) applications have exponentially expanded with the advent of molecular engineering strategies that have addressed many of the initial challenges, including improper light chain pairing, heterodimer purity, aggregation, and pharmacokinetics. However, the lack of high-through...

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Detalles Bibliográficos
Autores principales: Steinhardt, James, Wu, Yanli, Fleming, Ryan, Ruddle, Ben T., Patel, Pooja, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022642/
https://www.ncbi.nlm.nih.gov/pubmed/31861347
http://dx.doi.org/10.3390/pharmaceutics12010003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022642/
https://www.ncbi.nlm.nih.gov/pubmed/31861347
http://dx.doi.org/10.3390/pharmaceutics12010003

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