Insight into the Formation of Glimepiride Nanocrystals by Wet Media Milling

Nanocrystal formation for the dissolution enhancement of glimepiride was attempted by wet media milling. Different stabilizers were tested and the obtained nanosuspensions were solidified by spray drying in presence of mannitol, and characterized regarding their redispersibility by dynamic light sca...

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Detalles Bibliográficos
Autores principales: Medarević, Djordje, Ibrić, Svetlana, Vardaka, Elisavet, Mitrić, Miodrag, Nikolakakis, Ioannis, Kachrimanis, Kyriakos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022670/
https://www.ncbi.nlm.nih.gov/pubmed/31936609
http://dx.doi.org/10.3390/pharmaceutics12010053