Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia

In mammals, DNA methylation is necessary for the maintenance of genomic stability, gene expression regulation, and other processes. During malignant diseases progression, changes in both DNA methylation patterns and DNA methyltransferase (MTase) genes are observed. Human de novo MTase DNMT3A is most...

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Detalles Bibliográficos
Autores principales: A. Khrabrova, Daria, G. Loiko, Andrei, A. Tolkacheva, Anastasia, A. Cherepanova, Natalia, I. Zvereva, Maria, V. Kirsanova, Olga, S. Gromova, Elizaveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022712/
https://www.ncbi.nlm.nih.gov/pubmed/31861499
http://dx.doi.org/10.3390/biom10010008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022712/
https://www.ncbi.nlm.nih.gov/pubmed/31861499
http://dx.doi.org/10.3390/biom10010008

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