Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers through an Intrinsic Apoptosis Pathway

In order to discover novel derivatives in the anti-tumor field, reported anti-tumor pharmacophores (uridine, uracil, and thymine) were combined with 2-methoxyestradiol, which has been characterized as having excellent biological properties in terms of anti-tumor activity. Thus, 20 hybrids were synth...

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Detalles Bibliográficos
Autores principales: Sheng, Li-Xin, Zhang, Jiang-Yu, Li, Li, Xie, Xiao, Wen, Xiao-An, Cheng, Ke-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023064/
https://www.ncbi.nlm.nih.gov/pubmed/31936880
http://dx.doi.org/10.3390/biom10010123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023064/
https://www.ncbi.nlm.nih.gov/pubmed/31936880
http://dx.doi.org/10.3390/biom10010123

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