Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure

Lipid based formulations (LBFs) are commonly employed to enhance the absorption of highly lipophilic, poorly water-soluble drugs. However, the utility of LBFs can be limited by low drug solubility in the formulation. Isolation of ionizable drugs as low melting, lipophilic salts or ionic liquids (ILs...

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Detalles Bibliográficos
Autores principales: Tay, Erin, Nguyen, Tri-Hung, Ford, Leigh, Williams, Hywel D., Benameur, Hassan, Scammells, Peter J., Porter, Christopher J. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023222/
https://www.ncbi.nlm.nih.gov/pubmed/31877828
http://dx.doi.org/10.3390/pharmaceutics12010017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023222/
https://www.ncbi.nlm.nih.gov/pubmed/31877828
http://dx.doi.org/10.3390/pharmaceutics12010017

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