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Spatial Distribution of (R)-salbutamol in Rat Brain Following Nasal and Intravenous Administration Using DESI-MS

Recent studies have shown that β2-Adrenoreceptor is a regulator of the a-synuclein gene driving risk of Parkinson’s disease. The β2-AR agonist (R)-salbutamol, eutomer of rac-salbutamol, may hold therapeutic potential for Parkinson’s disease (PD) following nasal administration. In this study, we use...

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Detalles Bibliográficos
Autores principales: Zhang, Rui, Wu, Jie, Liu, Siyu, Deng, LiangJun, Hu, Junhua, Chen, Xi, Tan, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023290/
https://www.ncbi.nlm.nih.gov/pubmed/31906459
http://dx.doi.org/10.3390/pharmaceutics12010035