Vitamin B(12b) Enhances the Cytotoxicity of Diethyldithiocarbamate in a Synergistic Manner, Inducing the Paraptosis-Like Death of Human Larynx Carcinoma Cells

We have shown that hydroxycobalamin (vitamin B(12b)) increases the toxicity of diethyldithiocarbamate (DDC) to tumor cells by catalyzing the formation of disulfiram (DSF) oxi-derivatives. The purpose of this study was to elucidate the mechanism of tumor cell death induced by the combination DDC + B(...

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Detalles Bibliográficos
Autores principales: Solovieva, Marina, Shatalin, Yuri, Fadeev, Roman, Krestinina, Olga, Baburina, Yulia, Kruglov, Alexey, Kharechkina, Ekaterina, Kobyakova, Margarita, Rogachevsky, Vadim, Shishkova, Elena, Akatov, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023477/
https://www.ncbi.nlm.nih.gov/pubmed/31906414
http://dx.doi.org/10.3390/biom10010069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023477/
https://www.ncbi.nlm.nih.gov/pubmed/31906414
http://dx.doi.org/10.3390/biom10010069

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