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A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP

The application of in silico modeling to predict the in vivo outcome of an oral drug product is gaining a lot of interest. Fully relying on these models as a surrogate tool requires continuous optimization and validation. To do so, intraluminal and systemic data are desirable to judge the predicted...

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Detalles Bibliográficos
Autores principales:	Bermejo, Marival, Hens, Bart, Dickens, Joseph, Mudie, Deanna, Paixão, Paulo, Tsume, Yasuhiro, Shedden, Kerby, Amidon, Gordon L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023481/ https://www.ncbi.nlm.nih.gov/pubmed/31963448 http://dx.doi.org/10.3390/pharmaceutics12010074

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