Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1(+/−)-driven murine colonic adenomas

BACKGROUND: The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplicity. The tumors lack functional APC, and a geneti...

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Detalles Bibliográficos
Autores principales: Preston, Jessica L., Stiffler, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023705/
https://www.ncbi.nlm.nih.gov/pubmed/32059662
http://dx.doi.org/10.1186/s12885-020-6616-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023705/
https://www.ncbi.nlm.nih.gov/pubmed/32059662
http://dx.doi.org/10.1186/s12885-020-6616-y

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