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Epigenetic loss of heterozygosity of Apc and an inflammation-associated mutational signature detected in Lrig1(+/−)-driven murine colonic adenomas
BACKGROUND: The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with high penetrance and multiplicity. The tumors lack functional APC, and a geneti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023705/ https://www.ncbi.nlm.nih.gov/pubmed/32059662 http://dx.doi.org/10.1186/s12885-020-6616-y |