Cargando…
Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
BACKGROUND: Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is associated with microglial activation but not directly wit...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023749/ https://www.ncbi.nlm.nih.gov/pubmed/32059733 http://dx.doi.org/10.1186/s12974-020-01738-z |