Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice

BACKGROUND: Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is associated with microglial activation but not directly wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Lax, Neta, Fainstein, Nina, Nishri, Yossi, Ben-Zvi, Ayal, Ben-Hur, Tamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023749/
https://www.ncbi.nlm.nih.gov/pubmed/32059733
http://dx.doi.org/10.1186/s12974-020-01738-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023749/
https://www.ncbi.nlm.nih.gov/pubmed/32059733
http://dx.doi.org/10.1186/s12974-020-01738-z

Ejemplares similares