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Secretory clusterin promotes hepatocellular carcinoma progression by facilitating cancer stem cell properties via AKT/GSK-3β/β-catenin axis
BACKGROUND: To explore the modulatory effects and mechanism of secretory clusterin (sCLU) on cancer stem cell (CSC) properties in hepatocellular carcinoma (HCC). METHODS: The effects of sCLU repression or overexpression on chemoresistance, migration, invasion, and tumor growth were detected by MTT,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023808/ https://www.ncbi.nlm.nih.gov/pubmed/32059741 http://dx.doi.org/10.1186/s12967-020-02262-7 |