In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds

The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1, CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of CAMKK2 is linked to several diseases, suggesting the utility of CAMKK2 inhibitors for oncological, metabolic and inflammatory indi...

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Detalles Bibliográficos
Autores principales: O’Byrne, Sean N., Scott, John W., Pilotte, Joseph R., Santiago, André da S., Langendorf, Christopher G., Oakhill, Jonathan S., Eduful, Benjamin J., Couñago, Rafael M., Wells, Carrow I., Zuercher, William J., Willson, Timothy M., Drewry, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024175/
https://www.ncbi.nlm.nih.gov/pubmed/31941153
http://dx.doi.org/10.3390/molecules25020325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024175/
https://www.ncbi.nlm.nih.gov/pubmed/31941153
http://dx.doi.org/10.3390/molecules25020325

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