Simultaneous Quantitation of S(+)- and R(−)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC–APCI–MS/MS: An Application for Clinical Studies

Baclofen is a racemic mixture that is commonly used for the treatment for spasticity. However, the optimal dose and dosing interval to achieve effective cerebral spinal fluid (CSF) concentrations of baclofen are not known. Moreover, it is unclear if there are differences in the ability of R- or S-ba...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Qingfeng, Chhonker, Yashpal S., McLaughlin, Matthew J., Murry, Daryl J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024189/
https://www.ncbi.nlm.nih.gov/pubmed/31936209
http://dx.doi.org/10.3390/molecules25020250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024189/
https://www.ncbi.nlm.nih.gov/pubmed/31936209
http://dx.doi.org/10.3390/molecules25020250

Ejemplares similares