Profiling the Structural Determinants of Aryl Benzamide Derivatives as Negative Allosteric Modulators of mGluR5 by In Silico Study

Glutamate plays a crucial role in the treatment of depression by interacting with the metabotropic glutamate receptor subtype 5 (mGluR5), whose negative allosteric modulators (NAMs) are thus promising antidepressants. At present, to explore the structural features of 106 newly synthesized aryl benza...

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Detalles Bibliográficos
Autores principales: Zhao, Yujing, Chen, Jiabin, Liu, Qilei, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024197/
https://www.ncbi.nlm.nih.gov/pubmed/31963723
http://dx.doi.org/10.3390/molecules25020406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024197/
https://www.ncbi.nlm.nih.gov/pubmed/31963723
http://dx.doi.org/10.3390/molecules25020406

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