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Identification and Distribution of Novel Metabolites of Lolitrem B in Mice by High-Resolution Mass Spectrometry

Lolitrem B is the most potent indole-diterpene mycotoxin produced by Epichloë festucae var. lolii (termed LpTG-1), with severe intoxication cases reported in livestock. To date, there are no in vivo metabolism studies conducted for the mycotoxin. A mouse model assay established for assessing toxicit...

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Detalles Bibliográficos
Autores principales: Reddy, Priyanka, Elkins, Aaron, Hemsworth, Joanne, Guthridge, Kathryn, Vassiliadis, Simone, Read, Elizabeth, Spangenberg, German, Rochfort, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024290/
https://www.ncbi.nlm.nih.gov/pubmed/31963254
http://dx.doi.org/10.3390/molecules25020372