Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor

Voltage-gated sodium channels (Na(V)s) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) Na(V) subtype with saxitoxin (STX), a shellfish toxin, was determined. STX p...

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Detalles Bibliográficos
Autores principales: Adachi, Kanna, Ishizuka, Hayate, Odagi, Minami, Nagasawa, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024329/
https://www.ncbi.nlm.nih.gov/pubmed/31888062
http://dx.doi.org/10.3390/md18010024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024329/
https://www.ncbi.nlm.nih.gov/pubmed/31888062
http://dx.doi.org/10.3390/md18010024

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