Cargando…

One-Pot Multicomponent Synthesis and Cytotoxic Evaluation of Novel 7-Substituted-5-(1H-Indol-3-yl)Tetrazolo[1,5-a] Pyrimidine-6-Carbonitrile

A series of novel 7-substituted-5-(1H-indol-3-yl)tetrazolo[1,5-a]pyrimidine-6-carbonitrile was synthesized via a one-pot, three-multicomponent reaction of appropriate aldehydes, 1H-tetrazole-5-amine and 3-cyanoacetyl indole in catalytic triethylamine. The cytotoxic activity of the new synthesized te...

Descripción completa

Detalles Bibliográficos
Autores principales:	Radwan, Mohamed A. A., Alminderej, Fahad M., Awad, Hanem M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024365/ https://www.ncbi.nlm.nih.gov/pubmed/31936309 http://dx.doi.org/10.3390/molecules25020255

Ejemplares similares

A multicomponent tetrazolo indole synthesis
por: Lei, Xiaofang, et al.
Publicado: (2021)

Synthesis of tetrazolo[1,5-a]pyrimidine-6-carbonitriles using HMTA-BAIL@MIL-101(Cr) as a superior heterogeneous catalyst
por: Abdollahi-Basir, Mohammad Hossein, et al.
Publicado: (2021)

Synthesis, effect of substituents on the regiochemistry and equilibrium studies of tetrazolo[1,5-a]pyrimidine/2-azidopyrimidines
por: Scapin, Elisandra, et al.
Publicado: (2017)

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents
por: Wu, Liqiang, et al.
Publicado: (2018)

SnAr Reactions of 2,4-Diazidopyrido[3,2-d]pyrimidine and Azide-Tetrazole Equilibrium Studies of the Obtained 5-Substituted Tetrazolo[1,5-a]pyrido[2,3-e]pyrimidines
por: Leškovskis, Kristaps, et al.
Publicado: (2022)

4-Amino-6-(piperidin-1-yl)pyrimidine-5-carbonitrile
por: Bhat, Radhika, et al.
Publicado: (2020)

Design, Synthesis, and In Vitro Antimicrobial Evaluation of Fused Pyrano[3,2-e]tetrazolo[1,5-c]pyrimidines and Diazepines
por: Kanakaraju, Sankari, et al.
Publicado: (2013)

2-Anilino-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Mohamed, Shaaban K., et al.
Publicado: (2012)

Synthesis of 5-Substituted 3-Amino-1H-Pyrazole-4-Carbonitriles as Precursors for Microwave Assisted Regiospecific Syntheses of Pyrazolo[1,5-a]Pyrimidines
por: Al-Qalaf, Fawzia, et al.
Publicado: (2008)

7-Chloro-5-(chloromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Xu, Jingli, et al.
Publicado: (2012)

1-[(1-Methyl-1H-imidazol-5-yl)methyl]-1H-indole-5-carbonitrile
por: de Jager, Josephus Jacobus, et al.
Publicado: (2012)

Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides
por: Alminderej, Fahad M., et al.
Publicado: (2019)

Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents
por: Dave, Chaitanya G., et al.
Publicado: (2002)

7-(4-Chlorophenyl)-9-phenyl-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine
por: Shah, Rina D., et al.
Publicado: (2010)

7-(4-Bromophenyl)-9-phenyl-7H-pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine
por: Jotani, Mukesh M., et al.
Publicado: (2010)

1-Benzyl-2-(1H-indol-3-yl)-5-oxopyrrolidine-2-carbonitrile
por: Tamazyan, Rafael, et al.
Publicado: (2008)

Multifunctional derivatives of pyrimidine-5-carbonitrile and differently substituted carbazoles for doping-free sky-blue OLEDs and luminescent sensors of oxygen
por: Tsiko, Uliana, et al.
Publicado: (2021)

1,3-Dimethyl-1H-indole-2-carbonitrile
por: Li, Jiang-Sheng, et al.
Publicado: (2009)

An Efficient Three Component One-Pot Synthesis of 5-Amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles
por: Ablajan, Keyume, et al.
Publicado: (2012)

Synthesis of 4-(Phenylchalcogenyl)tetrazolo[1,5-a]quinolines by Bicyclization of 2-Azidobenzaldehydes with Phenylchalcogenylacetonitrile
por: Monzon, Loana I., et al.
Publicado: (2023)

Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles
por: Beyzaei, Hamid, et al.
Publicado: (2018)

6-(1H-Indol-3-yl)-4-phenyl-2,2′-bipyridine-5-carbonitrile
por: Zhu, Weijun, et al.
Publicado: (2009)

2-Benzylsulfanyl-4-pentyl-6-(phenylsulfanyl)pyrimidine-5-carbonitrile
por: El-Emam, Ali A., et al.
Publicado: (2011)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
por: Lim, Felicia Phei Lin, et al.
Publicado: (2018)

Design and Evaluation of Novel Antimicrobial and Anticancer Agents Among Tetrazolo[1,5-c]quinazoline-5-thione S-Derivatives
por: Antypenko, Lyudmyla M., et al.
Publicado: (2013)

Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents
por: Abdou, Wafaa M, et al.
Publicado: (2013)

Synthesis of pyrimidine-6-carbonitriles, pyrimidin-5-ones, and tetrahydroquinoline-3-carbonitriles by new superb oxovanadium(V)-[5,10,15,20-tetrakis(pyridinium)-porphyrinato]-tetra(tricyanomethanide) catalyst via anomeric based oxidation
por: Dashteh, Mohammad, et al.
Publicado: (2022)

(±)-trans-5-Benzoyl-2-(1H-indol-3-yl)-4-phenyl-4,5-dihydrofuran-3-carbonitrile
por: Suresh, J., et al.
Publicado: (2012)

2-Methyl-1-phenyl-1H-indole-3-carbonitrile
por: Yang, Kun, et al.
Publicado: (2011)

Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles
por: Trawczyński, Adam, et al.
Publicado: (2013)

NMR-Verified Dearomatization of 5,7-Substituted Pyrazolo[1,5-a]pyrimidines
por: Novikova, Daria, et al.
Publicado: (2023)

7-(2,4-Dichlorophenyl)-2-methylsulfanylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
por: Wen, Li-rong, et al.
Publicado: (2009)

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as Novel Potential Anticancer Agents: Cytotoxic and Genotoxic Activities In Vitro
por: Bukowski, Karol, et al.
Publicado: (2022)

(5Z,7Z)-6,8-Dimethyl-9H-tetrazolo[1,5-b][1,2,4]triazepine
por: He, Chun-Lin, et al.
Publicado: (2009)

In water multicomponent synthesis of low-molecular-mass 4,7-dihydrotetrazolo[1,5-a]pyrimidines
por: Tkachenko, Irina G, et al.
Publicado: (2019)

4-(4-Bromophenyl)-6-(1H-indol-3-yl)-2,2′-bipyridine-5-carbonitrile
por: Ramesh, P., et al.
Publicado: (2009)

5-Benzoyl-2-(1H-indol-3-yl)-4-(4-methylphenyl)-4,5-dihydrofuran-3-carbonitrile
por: Suresh, J., et al.
Publicado: (2012)

4-(Piperidin-1-yl)-4H-benzo[b]tetrazolo[1,5-d][1,4]diazepin-5(6H)-one
por: Nichol, Gary S., et al.
Publicado: (2010)

Structural Necessity of Indole C5-O-Substitution of seco-Duocarmycin Analogs for Their Cytotoxic Activity
por: Choi, Taeyoung, et al.
Publicado: (2010)

Scope of tetrazolo[1,5-a]quinoxalines in CuAAC reactions for the synthesis of triazoloquinoxalines, imidazoloquinoxalines, and rhenium complexes thereof
por: Holzhauer, Laura, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_is5fuhlcs31lrblia875hra1rp