Design, Synthesis, and In Vitro Evaluation of the Photoactivatable Prodrug of the PARP Inhibitor Talazoparib

In this article, we report the design, synthesis, photodynamic properties, and in vitro evaluation of photoactivatable prodrug for the poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor Talazoparib. In order to yield a photoactivatable, inactive prodrug, photoactivatable protecting groups (PPGs) were...

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Detalles Bibliográficos
Autores principales: Li, Jiaguo, Xiao, Dian, Liu, Lianqi, Xie, Fei, Li, Wei, Sun, Wei, Yang, Xiaohong, Zhou, Xinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024556/
https://www.ncbi.nlm.nih.gov/pubmed/31963730
http://dx.doi.org/10.3390/molecules25020407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024556/
https://www.ncbi.nlm.nih.gov/pubmed/31963730
http://dx.doi.org/10.3390/molecules25020407

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